Taking biobased succinic acid as an example, the content of succinic acid produced in the fermentation broth is only a few percent, and the concentration is quite low. At the same time, the components inside are relatively complex, and it dissolves in the fermentation broth. The boiling point of succinic acid is high, extremely sensitive, and easy to form anhydride when heated, making separation difficult. However, DODGEN's treatment plan is to first esterification the fermentation broth to produce dimethyl succinate, and then distill/distill the dimethyl succinate from the reaction broth Here, obtain the preliminary concentrated dimethyl succinate. By further coupling crystallization, dimethyl succinate with a purity of over 99.5% was obtained. Dimethyl succinate can be further hydrogenated to generate BDO, or directly reacted with BDO to obtain a biodegradable material PBS, which is also a hot topic for future biodegradable materials.